Selected publications from the last 5 years
2010
Bergthaler A.#, L. Flatz, A.N. Hegazy, S. Johnson, E. Horvath, M. Löhning and D.D. Pinschewer. 2010. The viral replicative capacity is the primary determinant of lymphocytic choriomeningitis virus persistence and immunosuppression. Proceedings of the National Academy of Sciences USA 2010 Nov 22. (IF 9.59) (#corresponding author) PDF
Pinschewer D.D., L. Flatz, E. Horvath, M. Fernandez, R. Steinborn, M. Suter, H. Lutz and A. Bergthaler#. 2010. Innate and adaptive immune control of genetically engineered live-attenuated arenavirus vaccine prototypes. Int Immunol. 2010 Sep;22(9):749-56. Epub 2010 Jun 28. (IF 3.40) (#corresponding last author) PDF
Flatz, L.*, T. Rieger*, D. Merkler*, A. Bergthaler, T. Regen, M. Schedensack, L. Bestmann, A. Verschoor, M. Kreutzfeldt, W. Brück, U.K. Hanisch, S. Günther, and D.D. Pinschewer. 2010. Humanized MHC class I renders mice susceptible to Lassa fever. PLoS Pathogens 2010 6(3): e1000836. (IF 9.3) PDF
Pinschewer D.D., M. Schedensack, A. Bergthaler, E. Horvath, W. Brück, M. Löhning and D. Merkler. T cells can mediate viral clearance from ependyma but not parenchyma in a major histocompatibility class I- and perforin-independent fashion. Brain 2010 April. (IF 9.6) PDF
Flatz, L., A. Bergthaler*, A.N. Hegazy*, A. Verschoor*, A. Claus, M. Fernandez, L. Gattinoni, S. Johnson, F. Kreppel, S. Kochanek, M.v.d. Broek, A. Radbruch, F. Lèvy, P.H. Lambert, C.A. Siegrist, N.P. Restifo, M. Löhning, A.F. Ochsenbein, G.J. Nabel, and D.D. Pinschewer. 2010. Development of propagation-deficient arenavirus vaccine vectors for induction of potent CD8+ T cell immunity. Nature Medicine 2010 Febr 14 [Epub ahead of print]. (IF 26.3) (featured as Research Highlight in Nature Biotech and in Nature Reviews Immunology) PDF
Hegazy A.N., M. Peine, C. Helmstetter, I. Panse, A. Fröhlich, A. Bergthaler, L. Flatz, D. D. Pinschewer, A. Radbruch and M. Löhning. 2010. Interferon-mediated T-bet induction in T helper 2 cells prevents viral persistence and fatal immunopathology. Immunity 2010 Jan 13 [Epub ahead of print]. (IF 20.5) (Cover image and featured article, highlighted in Nature Reviews Immunology) PDF
2009
Bergthaler A. #, L. Flatz, A. Verschoor, A.N. Hegazy, M. Holdener, K. Fink, B. Eschli, D. Merkler, E. Horvath, M. Fernandez, A. Fitsche, B.M. Senn, B. Odermatt, C.A. Siegrist, and D.D. Pinschewer. 2009. Impaired antibody response allows persistence of prototypic T cell-contained virus. PLoS Biology 2009 Apr 7 7(4):e80. (IF 14.1) (#corresponding author) (featured as Research Highlight in Nature Reviews Immunology and as Must Read in Faculty of 1000) PDF
2007
Bergthaler A. #, D. Merkler, E. Horvath, L. Bestmann, and D.D. Pinschewer. 2007. Contributions of the lymphocytic choriomeningitis virus glycoprotein and polymerase to strain-specific differences in murine liver pathogenicity. Journal of General Virology 88:592-603. (IF 3.1) (#corresponding author) PDF
Recher, M., K.S. Lang, A. Navarini, L. Hunziker, P.A. Lang, K. Fink, S. Freigang, P. Georgiev, L. Hangartner, R. Zellweger, A. Bergthaler, A.N. Hegazy, B. Eschli, A. Theocharides, L.T. Jeker, D. Merkler, B. Odermatt, M. Hersberger, H. Hengartner, and R.M. Zinkernagel. 2007. Extralymphatic virus sanctuaries as a consequence of potent T-cell activation. Nature Medicine 13:1316-1323. (IF 26.3) PDF
Lang, K.S., A.A. Navarini, M. Recher, P.A. Lang, M. Heikenwalder, B. Stecher, A. Bergthaler, B. Odermatt, S. Akira, K. Honda, H. Hengartner, and R.M. Zinkernagel. 2007. MyD88 protects from lethal encephalitis during infection with vesicular stomatitis virus. European Journal of Immunology 37:2434-2440. (IF 4.6) PDF
2006
Lang, K.S., P. Georgiev, M. Recher, A.A. Navarini, A. Bergthaler, M. Heikenwalder, N.L. Harris, T. Junt, B. Odermatt, P.A. Clavien, H. Pircher, S. Akira, H. Hengartner, and R.M. Zinkernagel. 2006. Immunoprivileged status of the liver is controlled by Toll-like receptor 3 signaling. Journal of Clinical Investigations 116:2456-2463. (IF 16.9) (featured as a Must Read in Faculty of 1000) PDF
Navarini, A.A., M. Recher, K.S. Lang, P. Georgiev, S. Meury, A. Bergthaler, L. Flatz, J. Bille, R. Landmann, B. Odermatt, H. Hengartner, and R.M. Zinkernagel. 2006. Increased susceptibility to bacterial superinfection as a consequence of innate antiviral responses. Proceedings of the National Academy of Sciences USA 103:15535-15539. (IF 9.59) PDF
Bergthaler, A.*, L. Flatz*, J.C. de la Torre and D.D. Pinschewer. 2006. Recovery of an arenavirus entirely from RNA polymerase I/II-driven cDNA. Proceedings of the National Academy of Sciences USA 103:4663-4668. (* these authors contributed equally) (IF 9.59) PDF
Bergthaler, A., N.U. Gerber, D. Merkler, E. Horvath, J.C. de la Torre, and D.D. Pinschewer. 2006. Envelope exchange for the generation of live-attenuated arenavirus vaccines. PLoS Pathogens 2:e51. (IF 9.3) PDF